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English blog (70) : 「Genetic diagnosis」:the 27th AOFOG conference (2)

The topic of Matsumi Ladies Clinic Mita English blog in April is about the 27th AOFOG conference.

In the first part, I create an article about an introduction of this conference.

 

In May, the 27th Asian-Oceania Federation of Obstetrics and Gynecology (AOFOG) conference will be held in Bali, Indonesia.

The deadline for submission of presentations at academic conferences is April 30, thus I have been worked along with daily medical care in recent weeks.

From now on, I would like to explain two presentations one by one.

 

The title of the first presentation is “Successful prenatal genetic diagnosis for pregnant a woman with a history of a history of pregnancies with 7-involving abnormalities.”

 

This presentation is a joint project with 5 doctors, belong to 4 facilities.

The second author, Associate Professor Takeshi Nagamatsu and Dr. Tatsuya Fujii, who helps our clinic every Monday, belong to Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Dr. Momoeda, who was Deputy Director of St. Luke’s International Hospital at the time of submission of this abstract, is now Director of Aiiku Hospital, Tokyo, Japan.

The last author is Director Tomoyuki Fujii in Department of Obstetrics and Gynecology, Sanno Hospital, International University of Health and Welfare, Tokyo, Japan.

 

The abstract of this presentation is as described below.

 

「Successful prenatal genetic diagnosis for a pregnant woman with a history of repetitive pregnancies with chromosome 7-involving abnormalities.」

the 27th Asia Oceania Federation of Obstetrics and Gynecology, Bali(Indonesia) May 2022

1.Hirotaka Matsumi, 2. Takeshi Nagamatsu, 2. Tatsuya Fujii, 3. Mikio Momoeda, 4. Tomoyuki Fujii.

 

1. MATSUMI Ladies Clinic Mita, Tokyo, Japan
2. Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
3. Department of Obstetrics and Gynecology, Aiiku Hospital, Tokyo, Japan
4. Department of Obstetrics and Gynecology, Sanno Hospital, International University of Health and Welfare, Tokyo, Japan

 

Objectives: Since available methods for genetic analysis are increasing, the selection of the diagnostic approach responding to concerns of individual woman is important in prenatal genetic counseling.

We hereby document a case of prenatal genetic diagnosis in which combination of G-banding and SNP microarray was required for a pregnant woman with an obstetrical history of repetitive genetic problems involving chromosome 7.

 

Case: A 38-year-old woman G3P1 visited us following spontaneous conception.

In her first child, 7q11.23 deletion had been diagnosed after birth.

In her second pregnancy, she had undergone amniocentesis, consequently detecting 30% mosaicism for trisomy 7.

Then, the pregnancy had been terminated at 21 weeks of gestation.

 

At her first visit in the third pregnancy, she was severely concerned about possible genetic disorders in the fetus.

Prenatal counseling regarding the available methods of prenatal genetic diagnosis was provided and she opted to have amniocentesis with combined diagnosis by G-banding and SNP microarray analysis.

Resultantly, no genetic abnormality was confirmed in the fetus, contributing to the relieve of her concern.

Finally, she delivered a healthy girl of 3340g at 39 weeks of gestation.

 

Conclusions: Combination of G-banding with SNP microarray was appropriate in this case to deny possibilities of microstructure abnormality and mosaicism.

 

I will add some explanations of this presentation from next blog step by step.

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